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Margarita Ivanova, PhD
Director of Translational Research Unit

Research interests are at the intersection of lysosomal storage disorders, new biomarkers development, and novel therapies. One focus area is the development and implementation of individual screening of novel therapies for patients with rare genetic diseases. My studies include many aspects of translational research utilizing experimental contributions to the fields of autophagy-lysosomal pathway, mitochondrial function, and sphingolipid metabolism.

Email: margarita.ivanova@ldrtc.org | mivanova@ldrtc.org
My Publications

My Work

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Recent Publications •

 

1. Goker-Alpan O, Ivanova MM, Pathak R, Wright. Enzyme replacement therapy in infants and very young children with Gaucher disease using velaglucerase alfa: a single-center experience.  E.Front Pediatr. 2025 Oct 17;13:1613599. doi: 10.3389/fped.2025.1613599. eCollection 2025.

2. Ivanova MM, Dao J, Kasaci N, Huang F, Nguyen E, Goker-Alpan O. Age-related inflammatory biomarkers in early-onset osteoporosis in females with Gaucher disease. Front Endocrinol (Lausanne). 2025 Jul 2;16:1606218. doi: 10.3389/fendo.2025.1606218. eCollection 2025.

 

3. Svarny L, Agha A, Dao J, Sandhu B, Ivanova M, Goker-Alpan O. The clinical utility of neurofilament light chain for early detection and prediction of disease burden and severity in neuronopathic Gaucher disease. Mol Genet Metab. 2025 Aug;145(4):109181. doi: 10.1016/j.ymgme.2025.109181. Epub 2025 Jun 19. PubMed PMID: 40570595.

4. Ivanova MM, Dao J, Friedman A, Kasaci N, Goker-Alpan O. Sex Differences in Circulating Inflammatory, Immune, and Tissue Growth Markers Associated with Fabry Disease-Related Cardiomyopathy. Cells. 2025 Feb 20;14(5). doi: 10.3390/cells14050322. PubMed PMID: 40072051; PubMed Central PMCID: PMC11899294.

5. Goker-Alpan O, Ivanova MM. Neuronopathic Gaucher disease: Rare in the West, common in the East. J Inherit Metab Dis. 2024 Sep;47(5):917-934. doi: 10.1002/jimd.12749. Epub 2024 May 20. Review. PubMed PMID: 38768609.