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Margarita Ivanova, PhD
Director of Translational Research Unit

Research interests are at the intersection of lysosomal storage disorders, new biomarkers development, and novel therapies. One focus area is the development and implementation of individual screening of novel therapies for patients with rare genetic diseases. My studies include many aspects of translational research utilizing experimental contributions to the fields of autophagy-lysosomal pathway, mitochondrial function, and sphingolipid metabolism.

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My Publications

My Work


Recent Publications •

Ivanova M, Dao J, Noll L, Fikry J, Goker-Alpan O. TRAP5b and RANKL/OPG Predict Bone Pathology in Patients with Gaucher Disease. J Clin Med. 2021 May 20;10(10). doi: 10.3390/jcm10102217. PubMed PMID: 34065531.

Ivanova MM ,  Dao J,  Kasaci N,  Adewale B,  Nazari S, Noll L,  Fikry J,  Sanati A, Ozlem Goker-Alpan. Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease. PlosOne.  2021. Print

Limgala RP,  Furtak V,  Ivanova MM, Changsila E,  Wilks F,  FideliaLambert MN, Goker-Alpan O,  Gondré Lewis MC. Selective screening for lysosomal storage disorders in a large cohort of minorities of African descent shows high prevalence rates and novel variants. JIMD reports. 2021.

Ivanova MM. Altered sphingolipids metabolism damaged mitochondrial functions: lessons learned from Gaucher and Fabry diseases. J. Clin. Med. 2020, 9(4), 1116

Ivanova MM,  Dao  J,  Kasaci N,  Adewale B,  Fikry J ,  Goker-Alpan O. Rapid clathrin-mediated uptake of recombinant α-gal-a to lysosome activates autophagy. Biomolecules. 2020, May 30;10(6):E837